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  • Applications
    • In-line 100% container closure integrity inspection
    • In process control of headspace oxygen
    • In-line vacuum leak detection
    • In-line moisture determination of lyophilized vials
    • Nitrogen purge optimization and qualification
    • Headspace oxygen stability studies
    • Container closure integrity testing
    • Packaging permeation studies
    • Lyo chamber moisture mapping
    • Lyo cycle optimization
    • Lyo product stability studies
    • Water activity measurements
  • Headspace Systems
    • PULSAR Headspace Inspection System
    • PULSAR Headspace CCI Inspection Lease System
    • FMS-Oxygen Headspace Analyzer
    • FMS-Moisture/Pressure Headspace Analyzer
    • FMS-Carbon Dioxide Headspace Analyzer
    • FMS-Water Activity Analyzer
    • FMS-Flexible Bag Headspace Analyzer
  • Measurement Services
    • Laboratory Measurement Services
    • On-Site Measurement Services
    • Benchtop Equipment Lease
    • Automated Inspection Machine Lease
 

Product Notes

FMS-Oxygen Headspace Analyzer
FMS-Moisture/Pressure Headspace Analyzer
FMS-Water Activity Analyzer
Measurement Services
FMS-Carbon Dioxide Headspace Analyzer
Container Closure Integrity Testing
FMS GxP Database Software
PULSAR Headspace CCI Inspection Lease System
PULSAR Headspace Inspection System

Presentations

100% Headspace Analysis for Characterization & Optimization of Sterile Manufacturing Processes
Container Closure Workshop 2010
Alternatives to the Dye Test 2010
Raised Stopper Detection: Visual Inspection versus Headspace Inspection
Laser-Based Headspace Inspection: Moisture Mapping across Freeze Dryer Shelves
Correlating Vial Seal Tightness to Container Closure Integrity at Various Storage Temperatures
Lighthouse Webinar for USP<1207>, March 2016

Pharmaceutical Online

Main page
LIGHTHOUSE page

Application Notes

Stopper "Pop-Up" and the Effects on Container Closure of Sterile Vials
In-Process Monitoring of Headspace Oxygen Levels in Parenteral Containers
Detecting Raised Stoppers in Sterile Freeze Dried Vials
Headspace Oxygen Monitoring and Container Closure Integrity Testing of Pre-Filled Syringes

Posters

Performance Data and Validation Strategies for the VISTA In-Line Oxygen Detection System
Case Study: Container Closure Considerations for Coated Stoppers
Raised Stopper Detection in Freeze Dried Vials: Visual Inspection vs. Headspace Inspection
A Rapid & Nondestructive Method for Monitoring Oxygen in Parenteral Containers: Assessing Oxidative Degradation.
Using 100% Headspace Inspection for Characterizing and Optimizing Parenteral Manufacturing Processes
Non-destructive headspace moisture detection for lyo cycle optimization and 100% inspection of the finished product
Non-Destructive Monitoring of Oxygen in Pre-Filled Syringes
Freeze dried cakes –Where is the water?
Case Study: 100% Container Closure Integrity Inspection of Dual Chamber Freeze-Dried Cartridges
CCIT and Headspace Oxygen Monitoring in Pre-filled Syringes
Oxygen Permeation Rates Through Syringe Components

Other

Lighthouse La Vague CCI article
Lighthouse October 2014 conference presentation abstracts

Customer Notes

Case Study: 100% Container Closure Inspection of Freeze Dried Drug Product in Quarantine
Case Study: Container Closure Integrity Testing for Sterile Vial Products in Deep Cold Storage

White Papers

Introduction to Laser-Based Headspace Inspection and the Application to 100% Container Closure Inspection of Sterile Pharmaceutical Containers
Using Laser-Based Headspace Moisture Analysis for Rapid Nondestructive Moisture Determination of Sterile Freeze-Dried Product
LIGHTHOUSE Company Brochure

Technical Notes

CCI in lieu of Sterility Testing
Filling Line Purge Optimization & Validation
CCI of Sterile Vials During Deep Cold Storage
Microbial Detection with Laser-Based Headspace Analysis
Sterile production process studies using 100% headspace inspection of finished product

 

 

 

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