The FMS-Carbon Dioxide Headspace Analyzer is a non-destructive gas analyzer for monitoring headspace carbon dioxide concentration in sealed parenteral containers. This compact benchtop instrument utilizes a patented laser absorption technique developed with funding from the Food and Drug Administration.
Light from a near-infrared diode laser is tuned to match an internal absorption frequency of the carbon dioxide molecule and passed through the empty container headspace above the product. The amount of laser light absorbed is proportional to the carbon dioxide concentration in the headspace. The measurement method is rapid and non-destructive. These characteristics allow for multiple measurements on the same sample enabling the accurate monitoring of the headspace carbon dioxide level of a single sample over time. Because the sample is not destroyed there are no waste disposal issues and potentially valuable product can be saved for other tests.
The analyzer is a robust solid state device and is straightforward to use. Operators do not require special expertise to run the system meaning the accuracy of the measurements does not depend on operator skill.
The FMS-Carbon Dioxide Headspace Analyzer is used for development and QC laboratory applications as well as for at-line in-process control of headspace carbon dioxide levels in production. Systems can be permanently situated in laboratories for product and/or package- development, or mounted on carts and wheeled from line to line for in-process monitoring and troubleshooting activities.
Applications include:
• Container closure integrity testing of frozen product stored on dry ice for transport
• IPC monitoring of carbon dioxide levels during the filling of product purged with carbon dioxide in the headspace
• Microbial growth detection in media vials
New Generation FMS Demonstration
