Amsterdam Science Park. As the recognized experts in laser-based headspace analysis, LIGHTHOUSE supplies headspace analysis platforms as well as analytical services for the pharmaceutical and biotech industries.

by taking advantage of the wide variety of analytical headspace services. Samples can be sent to LIGHTHOUSE for analysis, equipment can be brought on site by LIGHTHOUSE Application Scientists, or equipment can be made available for short term lease.

Container closure studies, container closure inspection, vacuum determination, headspace oxygen determination, moisture determination, lyo chamber moisture mapping, and lyo cycle optimization.

Container closure studies, headspace oxygen monitoring, nitrogen purge optimization and validation, and headspace oxygen determination for stability and end-of-shelf-life studies. Permeation studies can be done in plastic containers for oxygen, water vapor, and carbon dioxide.

include validated benchtop analyzers for headspace oxygen, moisture (water activity), carbon dioxide, and vacuum analysis. Automated machines for 100% inspection can be arranged for lease projects.

gained from analyzing millions of samples from sterile drug facilities all over the world. This experience enables LIGHTHOUSE to not only generate the analytical data but to also support the client in using the data to optimize processes and define best practices.

to perform analytical studies. As a science-based company, LIGHTHOUSE believes the increasing generation of analytical data for process and product understanding will drive quality in the pharmaceutical industry for the coming decade.

LIGHTHOUSE commercialized the laser-based headspace method almost 15 years ago with funding from the FDA. Since then the technique has enabled innovative applications such as making headspace oxygen measurements in small syringes and ampoules in a rapid and non-destructive manner.

The rapid non-destructive nature of the measurement has enabled 100% container closure integrity inspection as well as 100% headspace oxygen monitoring for oxygen-sensitive product. The technique can also be used as a rapid microbiological method.